The Yorkshire Aid Convoy, set up in 2002 by Wetheralds Painters & Building Services, makes annual trips to either Romania or Ukraine.
This year it has been given 80,000 school exercise books to take.
The convoy will carry over 50 tonnes of donated goods worth over £2.5m on a 3,000-mile round trip which will visit schools, hospitals, care homes, disabled centres and business start-ups.
It will leave the UK on 2 May.
LSS Waste general manager Ian Grimes and owner Nigel Woolford will also volunteer as drivers.
Mark Murphy of the Yorkshire Aid Convoy said: “It’s a massive annual undertaking to get the convoy up, running and on the road, and one that couldn’t be done without the hard work and commitment of all the volunteers who help us through the year, as well as on the trip itself.
“It is worth every single second of the work being put in when you see the reception the donations receive when we deliver them – and hopefully this year we’ll see a lot of smiling faces when we hand over all the crayons collected through LSS Waste.”
Those wishing to donate can post to LSS Waste or alternatively call the Leeds branch to arrange for your donation to be picked up.